Prognostic Value of Activated Toll-Like Receptor-4 in Monocytes Following Acute Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction.
In the present study, we observed the expression of toll-like receptor 4 (TLR4) and its downstream signal pathway in peripheral blood monocytes (PBMs) from patients with acute cerebral infarct (ACI). The expression of TLR4 and MyD88 by PBMs was determined by flow cytometry and reverse transcriptase-polymerase chain reaction, and nuclear factor-kappaB (NF-kappaB) activity was detected by electro...
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Objective(s): Stroke is known as a main cause of mortality and prolonged disability in adults. Both transient receptor potential V1 (TRPV1) channels and toll-like receptors (TLRs) are involved in mediating the inflammatory responses. In the present study, the effects of TRPV1 receptor activation and blockade on stroke outcome and gene expression of TLR2 and TLR4 were assessed following permanen...
متن کاملExpansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome.
BACKGROUND Atherosclerosis is an inflammatory disease in which monocytes and macrophages have been suggested to play an essential role. The underlying signaling mechanisms are unknown thus far. We hypothesized that the human isoform of Toll-like receptor (hTLR)-4 is involved in monocyte activation of patients with accelerated forms of atherosclerosis. METHODS AND RESULTS Expression of hTLR4 o...
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ژورنال
عنوان ژورنال: International Heart Journal
سال: 2008
ISSN: 1349-2365,1349-3299
DOI: 10.1536/ihj.49.1